{"id":18059,"date":"2025-02-10T18:22:17","date_gmt":"2025-02-10T09:22:17","guid":{"rendered":"https:\/\/hyperpast-journal.xyz\/?p=18059"},"modified":"2025-02-10T18:22:17","modified_gmt":"2025-02-10T09:22:17","slug":"post-18059","status":"publish","type":"post","link":"https:\/\/journal.mitoflow40.com\/?p=18059","title":{"rendered":"\u305d\u3082\u305d\u3082\u7cd6\u8cea\u3063\u3066\u60aa\u306a\u306e\uff1f\uff1f\uff1a40\u4ee3\u304b\u3089\u306e\u5065\u5eb7\u5b66\u7fd2 &#8211; \u30d8\u30eb\u30b9\u30e9\u30fc\u30cb\u30f3\u30b0\u30b8\u30e3\u30fc\u30ca\u30eb #06"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-align-left\">\u306f\u3058\u3081\u306b<\/h2>\n\n\n\n<p>\u904e\u53bb\u306e\u51fa\u6765\u4e8b\u3001\u6280\u8853\u3001\u601d\u60f3\u3092\u672a\u6765\u306e\u8996\u70b9\u304b\u3089\u518d\u89e3\u91c8\u3059\u308b\u305f\u3081\u306b\u66f8\u304d\u6b8b\u3059\u30d6\u30ed\u30b0\u30e1\u30c7\u30a3\u30a2 Hyperpast Journal\uff08\u30cf\u30a4\u30d1\u30fc\u30d1\u30b9\u30c8\u30b8\u30e3\u30fc\u30ca\u30eb\uff09\u3002\u66f8\u304d\u624b\u306f\u6620\u50cf\u30af\u30ea\u30a8\u30a4\u30bf\u30fc\u306e<a href=\"https:\/\/shinealight.studio.site\/\" target=\"_blank\" rel=\"noreferrer noopener\">DAISUKE KOBAYASHI<\/a>\u3067\u3059\u3002<\/p>\n\n\n\n<p>#06\u3067\u306f\u3001\u305d\u3082\u305d\u3082\u7cd6\u8cea\u3092\u6442\u308b\u3053\u3068\u3063\u3066\u99c4\u76ee\u306a\u306e\uff1f\u306a\u305c\u99c4\u76ee\u306a\u306e\uff1f\u3068\u3044\u3063\u305f\u7591\u554f\u304c\u3001#01\u304b\u3089\u66f8\u3044\u3066\u304d\u305f\u3053\u3068\u3092\u6539\u3081\u3066\u8aad\u307f\u8fd4\u3057\u3066\u307f\u308b\u3068\u6d6e\u304b\u3093\u3067\u304f\u308b\u3088\u3046\u306b\u611f\u3058\u307e\u3059\u3002\u305d\u3046\u3057\u305f\u7591\u554f\u306e\u7b54\u3048\u3068\u3057\u3066\u4eca\u56de\u306f\u8a18\u4e8b\u3092\u66f8\u3044\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eba\u985e\u304c\u7cd6\u8cea\u3092\u6442\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u80cc\u666f\u3068\u6b74\u53f2\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u73fe\u4ee3\u3067\u306f\u5f53\u305f\u308a\u524d\u306e\u3088\u3046\u306b\u306a\u308a\u3001\u305d\u3057\u3066\u7cd6\u8cea\u4e2d\u5fc3\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u306a\u305c\u826f\u304f\u306a\u3044\u306e\u304b\u3092\u7d10\u89e3\u304d\u66f8\u3044\u3066\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u975e\u5e38\u306b\u6839\u6df1\u3044\u554f\u984c\u3060\u3068\u611f\u3058\u3066\u3044\u308b\u305f\u3081\u3001\u3069\u3053\u307e\u3067\u8aac\u660e\u3067\u304d\u308b\u304b\u5206\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u3067\u304d\u308b\u9650\u308a\u5206\u304b\u308a\u3084\u3059\u304f\u66f8\u3044\u3066\u3044\u3051\u305f\u3089\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3061\u306a\u307f\u306b\u3001\u30d8\u30eb\u30b9\u30e9\u30fc\u30cb\u30f3\u30b0\u30b8\u30e3\u30fc\u30ca\u30eb\u3068\u306f\u300140\u4ee3\u306e\u50d5\u304c\u5b66\u3093\u3060\u6700\u65b0\u306e\u5065\u5eb7\u30fb\u6804\u990a\u306b\u95a2\u3059\u308b\u77e5\u8b58\u3092\u6574\u7406\u3057\u3001\u8a18\u4e8b\u5316\u3057\u3066\u767a\u4fe1\u3057\u3066\u3044\u304f\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002<\/p>\n\n\n\n<figure 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has-text-align-left\">\u7d4c\u6e08\u7684\u306a\u8981\u56e0\uff1a\u7cd6\u8cea\u306f\u300c\u5b89\u4fa1\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u304c\u826f\u3044\u300d<\/h3>\n\n\n\n<p>\u7cd6\u8cea\uff08\u7c73\u30fb\u30d1\u30f3\u30fb\u30d1\u30b9\u30bf\u30fb\u7802\u7cd6\uff09\u306f\u3001\u8089\u30fb\u9b5a\u30fb\u30ca\u30c3\u30c4\u3088\u308a\u5b89\u4fa1\u3067\u3001\u4f4e\u30b3\u30b9\u30c8\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u78ba\u4fdd\u3067\u304d\u308b\u305f\u3081\u3001\u8ca7\u56f0\u5c64\u306b\u3082\u666e\u53ca\u3057\u3084\u3059\u3044\u306e\u3067\u3059\u3002\u3067\u3059\u306e\u3067\u3001\u5404\u4f01\u696d\u306f\u5229\u76ca\u3092\u512a\u5148\u3057\u3001\u7cd6\u8cea\u4e3b\u4f53\u306e\u52a0\u5de5\u98df\u54c1\u3092\u5927\u91cf\u751f\u7523\u3092\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u300c\u5b89\u304f\u3066\u624b\u8efd\u306b\u98df\u3079\u3089\u308c\u308b\u98df\u54c1\uff1d\u7cd6\u8cea\u4e2d\u5fc3\u300d\u3068\u3044\u3046\u72b6\u6cc1\u304c\u751f\u307e\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u73fe\u4ee3\u306b\u304a\u3044\u3066\u3082\u5168\u304f\u5909\u308f\u308a\u306e\u306a\u3044\u69cb\u56f3\u3067\u3059\u3002\u3068\u3044\u3046\u3088\u308a\u3082\u3001\u3088\u308a\u52a0\u901f\u3057\u3066\u3044\u308b\u306e\u304c\u73fe\u4ee3\u3068\u8a00\u3048\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\uff1f<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-left\">\u7cd6\u8cea\u4f9d\u5b58\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff1a\u8133\u306e\u5831\u916c\u7cfb\u3068\u98df\u54c1\u7523\u696d<\/h3>\n\n\n\n<p>\u7cd6\u8cea\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u3092\u523a\u6fc0\u3057\u3001\u4f9d\u5b58\u6027\u3001\u4e2d\u6bd2\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u306e\u3067\u3001\u98df\u54c1\u696d\u754c\u306f\u98df\u3079\u305f\u304f\u306a\u308b\u8d85\u52a0\u5de5\u98df\u54c1\uff08UPF\uff09\u3092\u3088\u308a\u958b\u767a\u3057\u3001\u7cd6\u8cea\u4f9d\u5b58\u3092\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u7d50\u679c\u3068\u3057\u3066\u3001\u300c\u7cd6\u8cea\u3092\u6442\u3089\u306a\u3044\u3068\u843d\u3061\u7740\u304b\u306a\u3044\u300d\u300c\u3059\u3050\u306b\u7a7a\u8179\u3092\u611f\u3058\u308b\u300d\u3068\u3044\u3046\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u5b9a\u7740\u3059\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u306f\u8eab\u306b\u899a\u3048\u304c\u3042\u308b\u65b9\u3082\u591a\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u50d5\u81ea\u8eab\u3082\u539f\u4f53\u9a13\u3068\u3057\u3066\u7cd6\u8cea\u3092\u6fc0\u3057\u304f\u6442\u3063\u305f\u6b21\u306e\u65e5\u306f\u304a\u8179\u304c\u7a7a\u3044\u3066\u4ed5\u65b9\u304c\u306a\u3044\u3053\u3068\u304c\u591a\u3005\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u3044\u3064\u304b\u3089\u304b\u300c\u3042\u3001\u3053\u308c\u306f\u7cd6\u8cea\u3092\u6442\u308a\u3059\u304e\u3066\u3044\u308b\u305b\u3044\u3067\u304a\u8179\u304c\u7a7a\u304f\u3093\u3060\u2026\u300d\u3068\u6c17\u304c\u3064\u304d\u3001\u7cd6\u8cea\u3092\u610f\u8b58\u7684\u306b\u6e1b\u3089\u3057\u3066\u307f\u308b\u3068\u3001\u306a\u3093\u3068\uff01\u304a\u8179\u304c\u6e1b\u308b\u3053\u3068\u306f\u6e1b\u308a\u3001\u73fe\u5728\u306f1\u65e52\u98df\u306e\u98df\u751f\u6d3b\u3092\u9001\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3001\u76f4\u8fd1\u3060\u3068\u7cd6\u8cea\u3092\u3084\u305f\u3089\u6442\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u305f\u306e\u3067\u304a\u8179\u304c\u7a7a\u3044\u3066\u4ed5\u65b9\u304c\u3042\u308a\u307e\u305b\u3093\uff01\u3053\u308c\u306f\u3044\u308f\u3086\u308b\u7cd6\u4e2d\u6bd2\u3067\u3059\u306e\u3067\u3001\u6bd2\u304c\u629c\u3051\u308b\u307e\u3067\u306f\u8010\u3048\u308b\u3057\u304b\u3042\u308a\u307e\u305b\u3093\uff01<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-left\">\u5065\u5eb7\u6307\u5c0e\u30fb\u6804\u990a\u5b66\u306e\u8aa4\u89e3<\/h3>\n\n\n\n<p>1970\u5e74\u4ee3\u4ee5\u964d\u3001\u300c\u4f4e\u8102\u80aa\u30fb\u9ad8\u70ad\u6c34\u5316\u7269\u300d\u306e\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u307e\u3057\u305f\u3002\u300c\u8102\u8cea\uff1d\u60aa\u300d\u3068\u3044\u3063\u305f\u8aa4\u3063\u305f\u6982\u5ff5\u304c\u5e83\u307e\u308a\u3001\u7cd6\u8cea\u3092\u4e3b\u4f53\u3068\u3057\u305f\u98df\u4e8b\u304c\u3055\u3089\u306b\u4e00\u822c\u5316\u3059\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8fd1\u5e74\u3067\u306f\u300c\u7cd6\u8cea\u306e\u904e\u5270\u6442\u53d6\u304c\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0\u3067\u3042\u308b\u300d\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3057\u3066\u3001\u3053\u3053\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u306f\u7cd6\u8cea\u3067\u306f\u306a\u304f\u30b1\u30c8\u30f3\u4f53\u3092\u512a\u4f4d\u306b\u3059\u308b\u3053\u3068\u306e\u6709\u52b9\u6027\u3092\u8003\u3048\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\"><strong>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b\u3068\u73fe\u4ee3\u75c5\uff1a\u300c\u7570\u5e38\u306a\u3057\u300d\u3068\u8a00\u308f\u308c\u308b\u4e0d\u8abf\u306e\u80cc\u666f<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/journal.mitoflow40.com\/wp-content\/uploads\/33d194749efa8d79b10cf70e1496191a-1000x572.webp\" alt=\"\" class=\"wp-image-18087\"\/><\/figure>\n\n\n\n<p>\u73fe\u4ee3\u306e\u98df\u751f\u6d3b\u306f\u7cd6\u8cea\u4e2d\u5fc3\u306b\u504f\u3063\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u3055\u307e\u3056\u307e\u306a\u5065\u5eb7\u554f\u984c\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u75c5\u9662\u306e\u691c\u67fb\u3067\u306f\u300c\u7570\u5e38\u306a\u3057\u300d\u3068\u8a3a\u65ad\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u306e\u7d50\u679c\u3001\u591a\u304f\u306e\u4eba\u304c\u300c\u306a\u3093\u3068\u306a\u304f\u8abf\u5b50\u304c\u60aa\u3044\u304c\u3001\u539f\u56e0\u304c\u308f\u304b\u3089\u306a\u3044\u300d\u3068\u611f\u3058\u3066\u3044\u308b\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u50d5\u3068\u3066\u4f8b\u5916\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u3059\u306e\u3067\u3053\u3046\u3057\u3066\u8a18\u4e8b\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u66f8\u304d\u306a\u304c\u3089\u5b66\u3093\u3067\u3044\u308b\u306e\u3067\u3059\uff01<\/p>\n\n\n\n<p>\u3053\u306e\u80cc\u666f\u306b\u306f\u3001\u7cd6\u8cea\u4ee3\u8b1d\u3068\u4f53\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30b7\u30b9\u30c6\u30e0\u306b\u95a2\u3059\u308b\u6839\u672c\u7684\u306a\u554f\u984c\u304c\u5b58\u5728\u3059\u308b\u3068\u611f\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-left\"><strong>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b\u304c\u3082\u305f\u3089\u3059\u554f\u984c<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\"><strong>\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u3068\u6162\u6027\u708e\u75c7<\/strong><\/h4>\n\n\n\n<p>\u7cd6\u8cea\u3092\u904e\u5270\u306b\u6442\u53d6\u3059\u308b\u3068\u3001\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3068\u6025\u964d\u4e0b\u304c\u983b\u7e41\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u554f\u984c\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u904e\u5270\u5206\u6ccc \u2192 \u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd<\/li>\n\n\n\n<li>\u4f4e\u8840\u7cd6\u72b6\u614b \u2192 \u5026\u6020\u611f\u30fb\u96c6\u4e2d\u529b\u4f4e\u4e0b\u30fb\u30a4\u30e9\u30a4\u30e9<\/li>\n\n\n\n<li>\u708e\u75c7\u4fc3\u9032 \u2192 \u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u4f53\u5185\u306b\u5e83\u304c\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3057\u3066\u306f\u3001\u30a2\u30e1\u30ea\u30ab\u7cd6\u5c3f\u75c5\u5b66\u4f1a\uff08ADA\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\u3001TNF-\u03b1\uff09\u3092\u5897\u52a0\u3055\u305b\u3001\u6162\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Hotamisligil et al., 2006\uff09\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\"><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/strong><\/h4>\n\n\n\n<p>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b\u306f\u3001\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u306e\u4e3b\u8981\u30b7\u30b9\u30c6\u30e0\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u50cd\u304d\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u8102\u8cea\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u6d3b\u7528\u3059\u308b\u80fd\u529b\u3092\u6301\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u7cd6\u8cea\u3070\u304b\u308a\u6442\u53d6\u3057\u3066\u3044\u308b\u3068\u8102\u8cea\u4ee3\u8b1d\u304c\u5f31\u307e\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3084\u75b2\u52b4\u611f\u304c\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b \u2192 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30b9\u30c8\u30ec\u30b9\u5897\u52a0<\/li>\n\n\n\n<li>ATP\u304c\u52b9\u7387\u3088\u304f\u4f5c\u3089\u308c\u306a\u3044 \u2192 \u6162\u6027\u75b2\u52b4\u3001\u8133\u306e\u50cd\u304d\u306e\u4f4e\u4e0b<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3057\u3066\u306f\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001\u7cd6\u8cea\u904e\u5270\u6442\u53d6\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5897\u52a0\u3055\u305b\u3001\u7d30\u80de\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wallace, 2005\uff09\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\"><strong>\u7cd6\u8cea\u4f9d\u5b58\u306b\u3088\u308b\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u4e71\u308c<\/strong><\/h4>\n\n\n\n<p>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b\u306f\u3001\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u4e0a\u6607 \u2192 \u4ea4\u611f\u795e\u7d4c\u512a\u4f4d\uff08\u6162\u6027\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\uff09<\/li>\n\n\n\n<li>\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027 \u2192 \u6e80\u8179\u611f\u3092\u611f\u3058\u306b\u304f\u304f\u306a\u308a\u3001\u904e\u98df\u306b\u3064\u306a\u304c\u308b<\/li>\n\n\n\n<li>\u30bb\u30ed\u30c8\u30cb\u30f3\u4f4e\u4e0b \u2192 \u7cbe\u795e\u4e0d\u5b89\u5b9a\u3001\u3046\u3064\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3057\u3066\u306f\u3001\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7cd6\u8cea\u6442\u53d6\u306e\u5897\u52a0\u304c\u8133\u5185\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u5206\u6ccc\u3092\u6e1b\u5c11\u3055\u305b\u3001\u3046\u3064\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wurtman, 1995\uff09\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\">\u3053\u308c\u3089\u306f<strong>\u75c5\u9662\u3067\u306f\u300c\u7570\u5e38\u306a\u3057\u300d\u3068\u306a\u308b\uff1f<\/strong><\/h2>\n\n\n\n<p>\u7cd6\u8cea\u4e2d\u5fc3\u306e\u98df\u751f\u6d3b\u304c\u3082\u305f\u3089\u3059\u5065\u5eb7\u554f\u984c\u306f\u3001\u5f93\u6765\u306e\u8840\u6db2\u691c\u67fb\u3084\u5065\u5eb7\u8a3a\u65ad\u3067\u306f\u691c\u51fa\u3057\u306b\u304f\u3044\u3053\u3068\u304c\u554f\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\"><strong>\u73fe\u4ee3\u533b\u7642\u306e\u300c\u7570\u5e38\u306a\u3057\u300d\u306e\u57fa\u6e96\u304c\u554f\u984c<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u7cd6\u5024\u306e\u57fa\u6e96\u5024\uff0870\uff5e140mg\/dL\uff09\u306f\u98df\u5f8c\u306e\u6025\u4e0a\u6607\u3084\u4f4e\u8840\u7cd6\u306e\u5f71\u97ff\u3092\u898b\u843d\u3068\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u306f\u6b63\u5e38\u3067\u3082\u3001\u98df\u5f8c\u9ad8\u8840\u7cd6\uff08\u96a0\u308c\u7cd6\u5c3f\u75c5\uff09\u304c\u5b58\u5728\u3059\u308b\u5834\u5408\u304c\u3042\u308b<\/li>\n\n\n\n<li>HbA1c\uff08\u9577\u671f\u8840\u7cd6\u7ba1\u7406\u306e\u6307\u6a19\uff09\u304c6.0%\u672a\u6e80\u3067\u3082\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u9032\u3093\u3067\u3044\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u300c\u6b63\u5e38\u7bc4\u56f2\u5185\u300d\u306e\u8840\u7cd6\u5024\u3067\u3082\u3001\u98df\u5f8c\u9ad8\u8840\u7cd6\uff08\u96a0\u308c\u7cd6\u5c3f\u75c5\uff09\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u30922\u500d\u4ee5\u4e0a\u306b\u5897\u52a0\u3055\u305b\u308b\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u304c\u3042\u308a\u307e\u3059\uff08Gerstein et al., 2012\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\"><strong>\u4ee3\u8b1d\u306e\u7570\u5e38\u306f\u300c\u75c5\u6c17\u300d\u3067\u306f\u306a\u304f\u300c\u4e0d\u8abf\u300d\u3068\u3057\u3066\u6271\u308f\u308c\u308b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7cd6\u8cea\u904e\u591a\u306e\u5f71\u97ff\u306f\u300c\u75c5\u6c17\u300d\u3067\u306f\u306a\u304f\u3001\u300c\u751f\u6d3b\u7fd2\u6163\u306e\u554f\u984c\u300d\u3068\u307f\u306a\u3055\u308c\u3084\u3059\u3044<\/li>\n\n\n\n<li>\u300c\u7570\u5e38\u306a\u3057\u300d\uff1d\u300c\u75c5\u6c17\u3067\u306a\u3044\u300d \u3067\u306f\u306a\u304f\u3001\u300c\u691c\u67fb\u3067\u306f\u898b\u3048\u306a\u3044\u554f\u984c\u304c\u3042\u308b\u300d\u53ef\u80fd\u6027\u304c\u3042\u308b<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u75b2\u52b4\u611f\u3084\u982d\u75db\u3001\u96c6\u4e2d\u529b\u4f4e\u4e0b\u306f\u8840\u6db2\u691c\u67fb\u3067\u306f\u7570\u5e38\u3068\u3057\u3066\u73fe\u308c\u306a\u3044<\/li>\n<\/ul>\n\n\n\n<p>\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u6162\u6027\u75b2\u52b4\u75c7\u5019\u7fa4\uff08CFS\uff09\u306f\u7cd6\u4ee3\u8b1d\u7570\u5e38\u3068\u95a2\u9023\u304c\u3042\u308b\u304c\u3001\u5f93\u6765\u306e\u691c\u67fb\u3067\u306f\u8a3a\u65ad\u304c\u96e3\u3057\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Naviaux et al., 2016\uff09\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\">\u3067\u306f\u3001\u7cd6\u8cea\u4e2d\u5fc3\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306f\u300c\u3044\u3073\u3064\u300d\u306a\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>\u7d50\u8ad6\u3068\u3057\u3066\u3001\u30d2\u30c8\u306e\u4f53\u306e\u4ed5\u7d44\u307f\u3092\u8003\u3048\u308b\u3068\u3001\u7cd6\u8cea\u4f9d\u5b58\u306e\u73fe\u4ee3\u306e\u98df\u751f\u6d3b\u306f\u4e0d\u81ea\u7136\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d2\u30c8\u306e\u4f53\u306e\u672c\u6765\u306e\u4ed5\u7d44\u307f\u306f\u3001\u7cd6\u8cea\u306f\u7dca\u6025\u6642\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\uff08\u4e00\u6642\u7684\u306a\u88dc\u7d66\u306b\u306f\u9069\u3057\u3066\u3044\u308b\u304c\u3001\u6301\u7d9a\u529b\u304c\u306a\u3044\uff09\u3067\u3042\u308a\u3001\u8102\u8cea\u306f\u9577\u6642\u9593\u6301\u7d9a\u3059\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\uff08\u672c\u6765\u306f\u4f53\u8102\u80aa\u3092\u71c3\u713c\u3055\u305b\u308b\u30b7\u30b9\u30c6\u30e0\u304c\u5099\u308f\u3063\u3066\u3044\u308b\uff09\u3067\u3059\u3002\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u7cd6\u8cea\u4f9d\u5b58\u306e\u98df\u751f\u6d3b\u3067\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u6301\u7d9a\u3057\u306b\u304f\u304f\u3001\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u304c\u8d77\u3053\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3067\u306f\u3001\u3069\u3046\u3059\u308c\u3070\u3044\u3044\u306e\u304b\uff1f\u3068\u8003\u3048\u308b\u3068\u3001 \u7cd6\u8cea\u306e\u6442\u53d6\u3092\u9069\u5ea6\u306b\u6e1b\u3089\u3057\u3001\u8102\u8cea\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u5fc3\u306e\u98df\u4e8b\u306b\u30b7\u30d5\u30c8\u3059\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3057\u3001\u8d85\u52a0\u5de5\u98df\u54c1\uff08UPF\uff09\u3092\u98df\u3079\u308b\u306e\u306f\u907f\u3051\u3001\u539f\u578b\u306e\u6b8b\u3063\u3066\u3044\u308b\u81ea\u7136\u306a\u98df\u54c1\u30fb\u98df\u6599\u3092\u9078\u3073\u3001\u7cd6\u8cea\u306e\u6442\u53d6\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u306a\u304c\u3089\u30b1\u30c8\u30f3\u4f53\u3084\u8102\u80aa\u9178\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u6d3b\u7528\u3059\u308b\u306e\u304c\u30d2\u30c8\u3068\u3057\u3066\u81ea\u7136\u306a\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n<p>\u305d\u3046\u3059\u308b\u3053\u3068\u3067\u3001\u8b0e\u306e\u4f53\u8abf\u4e0d\u8abf\u3084\u73fe\u4ee3\u75c5\u306a\u3069\u3078\u306e\u5bfe\u7b56\u3092\u306f\u3058\u3081\u3066\u8b1b\u3058\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3001\u50d5\u306f\u611f\u3058\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading 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